Doped Nanocrystalline Calcium Carbonate-Phosphate – a Biomaterial for Bone Repair and Strengtheining by Drug Delivery

L. F. Koroleva; M. N. Dobrinskaya; I. S. Kamantsev

doi:10.17804/2410-9908.2015.5.147-157

L. F. Koroleva, M. N. Dobrinskaya, I. S. Kamantsev

DOPED NANOCRYSTALLINE CALCIUM CARBONATE-PHOSPHATE – A BIOMATERIAL FOR BONE REPAIR AND STRENGTHEINING BY DRUG DELIVERY

DOI: 10.17804/2410-9908.2015.5.147-157

It is demonstrated that doped nanocrystalline calcium carbonate-phosphate is a biocompatible material that influences actively the osteogenesis bone repair in fractures, strengthening of bone tissues for drug delivery regardless of age. The introduction of doped nanocrystalline calcium carbonate-phosphates into animals increases 5 times the mechanical strength of the bone tissue. The most durable bone may occur when doped silicon, iron and magnesium nanocrystalline calcium carbonate-phosphate is introduced into an animal. The results obtained indicate the possibility of producing bioceramics based on doped nanocrystalline calcium carbonate-phosphates.

Keywords: doped calcium carbonate-phosphate, bone repair, strengthening, drug delivery

References:

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$Fig. 1. Roentgenograms of the radial bone of a human limb: a – the course of fracture and transportation of doped nanocrystalline calcium carbonate-phosphate to the fracture within the first hours (shown by an arrow); b – the state after 2 weeks$ $Fig. 2. XRD patterns of iron, magnesium, zinc, gold calcium carbonate-phosphate doped with: x – diffraction lines of CaHPO4∙2H2O, o – diffraction lines of Ca5(PO4)3OH$ $Fig. 3. Mechanical fracture strength of bone tissue depending on the samples of doped calcium carbonate- phosphates used for the introduction into animals: point 1 on the x-axis is placebo, point 2 – sample 1, point 3 – sample 2, point 4 – sample 3$

Л. Ф. Королева, М. Н. Добринская, И. С. Каманцев

ДОПИРОВАННЫЙ НАНОКРИСТАЛЛИЧЕСКИЙ КАРБОНАТ-ФОСФАТ КАЛЬЦИЯ – БИОМАТЕРИАЛ ДЛЯ ВОССТАНОВЛЕНИЯ И УПРОЧНЕНИЯ КОСТЕЙ ПУТЕМ ТРАНСДЕРМАЛЬНОЙ ДОСТАВКИ

Показано, что допированный нанокристаллический карбонат-фосфат кальция является биосовместимым материалом, который активно воздействует на остеогенезис и ремонт костей при переломах, укрепление костной ткани путем чрезкожной доставки независимо от возраста. Введение допированного нанокристаллического карбонат-фосфат кальция животным увеличивает в 5 раз прочность костной ткани. Самая высокая прочность наблюдается, если вводится в организм допированный кремнием, железом и магнием нанокристаллический карбонат - фосфат кальция. Наши результаты указывают на возможность получения биокерамики на основе допированного нанокристаллического карбонат-фосфат кальция.

Ключевые слова: допированные карбонат-фосфаты кальция, восстановление кости, упрочнение, доставка лекарств

Библиография:

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Champion E. Sintering of calcium phosphate bioceramics // Acta Biomaterialia. – 2013. – Vol. 9, iss. 4. – P. 5855-5875. – DOI: 10.1016/j.actbio.2012.11.029.
Samar J. Kalita, Abhilasha Bhardwaj, Himesh A. Bhatt. Nanocrystalline calcium phosphate ceramics in biomedical engineering // Materials Science and Engineering: C. – 2007. – Vol. 27, iss. 3. – P. 441–449. – DOI: 10.1016/j.msec.2006.05.018.
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Nanocrystalline Hydroxyapatite Ceramics Produced by Low-Temperature Sintering after High-Pressure Treatment / A. S. Fomin, S. M. Barinov, Ievlev V. M., V. V. Smirnov, B. P. Mikhailov, E. K. Belonogov, N. A. Drozdova // Doklady Chemistry. – 2008. – Vol. 418, iss. 1. – P. 22–25. – DOI: 10.1134/S0012500808010084.
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Nanocrystalline hydroxyapatite for bone repair: an animal study / A. Brandt, S. Henning, G. Michler, W. Hein, A. Bernstein, M. Schulz // Journal of Materials Science: Materials in Medicine. – 2010. – Vol. 21, iss 1. – P. 283–294. – DOI: 10.1007/s10856-009-3859-1.
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Changes of Surface Composition and Morphology after Incorporation of Ions into Biomimetic Apatite Coatings / Wei Xia, Carl Lindahl, Cecilia Persson, Peter Thomsen, Jukka Lausmaa, Håkan Engqvist // Journal of Biomaterials and Nanobiotechnology. – 2010. – Vol. 1, no. 1. – P. 7–16. – DOI: 10.4236/jbnb.2010.11002.
Dorozhkin S. V. Biocomposites and hybrid biomaterials based on calcium orthophosphates // Biomatter. – 2011. – Vol. 1, iss 1. – P. 3–56. – DOI: 10.4161/biom.1.1.16782.
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Noor Zairin. Nanohydroxyapatite Application to Osteoporosis Management // Journal of Osteoporosis. – 2013. – Vol. 2013. – P. 1–6. – DOI: 10.1155/2013/679025.
Effect of ammonium carbonate on formation of calcium-deficient hydroxyapatite through double-step hydrothermal processing / S. Prakash Parthiban, Yong Kim, Koichi Kikuta, Chikara Ohtsuki // Journal of Materials Science: Materials in Medicine. – 2011. – Vol. 22, iss. 2. – P. 209–216. – DOI: 10.1007/s10856-010-4201-7.
Synthesis and physicochemical characterization of nanocrystalline chitosan-containing calcium carbonate apatites / Zh. A. Ezhova, E. M. Koval, N. A. Zakharov, V. T. Kalinnikov // Russian Journal of Inorganic Chemistry. – 2011. – Vol. 56, iss. 6. – P. 841–846. – DOI: 10.1134/S0036023611060076.
Barinov S. M. Calcium phosphate-based ceramic and composite materials for medicine // Russian Chemical Reviews. – 2010. – Vol. 79, iss. 1. – P. 13-29. – DOI: 10.1070/RC2010v079n01ABEH004098.
Shepherd Jennifer H., Shepherd David V., Best Serena M. Substituted hydroxyapatites for bone repair // Journal of Materials Science: Materials in Medicine. – 2012. – Vol. 23, iss. 10. – P. 2335–2347. – DOI: 10.1007/s10856-012-4598-2.
Koroleva L. F. Doped Nanocrystalline Calcium Carbonate Phosphates // Inorganic Materials. – 2010. – Vol. 46, iss. 4. – P. 405–411. – DOI: 10.1134/S0020168510040151.
Koroleva L. F., Larionov L. P., Gorbunova N. P. Doped calcium carbonate-phosphate-based biomaterial for active osteogenesis. Chapter 5. // Osteogenesis / ed. by Yunfeng Lin. – Croatia : InTech Publ., 2012. – ISBN 978-953-51-0030-0. – DOI: 10.5772/34119.
Koroleva L. F., Larionov L. P., Gorbunova N. P. Biomaterial based on doped calcium carbonate-phosphate for Active Osteogenesis // Journal of Biomaterials & Nanobiotechnology. – 2012. – Vol. 3, iss. 2. – P. 226–237. – DOI: 10.4236/jbnb.2012.32028.
Koroleva L. F., Cherednichenko N. V., Dobrinskaya M. N. Doped Nanocrystalline Calcium Carbonate-Phosphate Biomaterial with Transdermal Activity for Osteogenesis. Chapter 14 // Nanotechnology. Biomaterials. Vol. 11/ ed. by Naveen Kumar Shishir, Navani Sinh. – USA-India : STUDIUM PRESS LLC, 2014. – ISBN 1-626990-11-5.
Koroleva L. F. An oscillating mechanism in the synthesis of doped nanocrystalline calcium carbonate phosphates // Nanotechnologies in Russia. – 2010. – Vol. 5, iss. 9–10. P. 635–640. – ISSN 1995-0780.
Development of new biologically active material for bone reconstruction and evaluation of its application security / L. P. Larionov, L. F. Koroleva, E. F. Gaysina, M. N. Dobrinskaya // Biomeditsina. – 2011. – No. 4. – P. 101–103. (In Russian).
Principles of demineralization: Modern strategies for the isolation of organic frameworks. Part II. Decalcification / Hermann Ehrlich, Petros G. Koutsoukos, Konstantinos D. Demadis, Oleg S. Pokrovsky // Micron. – 2009. – Vol. 40, iss. 2. – P. 169–193. – DOI:10.1016/j.micron.2008.06.004.
Synthesis and physical chemical research of calcium carbonate-hydroxyapatite of type A / G. V. Rodicheva, V. P. Orlovsky, V. P. Privalov, S. M. Barinov, F. S. Pustikelli, S. Oskarson // Russian Journal Inorganic Chemistry. – 2001. – Vol. 46, iss. 11. – P. 1798–1802.
Lafon J. P., Champion E., Bernache-Assolant D. Processing of AB-type carbonated hydroxyapatite Ca10-x (PO4)6-x(CO3)x (OH)2-x-2y(CO3)y ceramics with controlled composition // Journal of the European Ceramic Society. – 2008. – Vol. 28, iss. 1. – P. 139–147. – DOI: 10.1016/j.jeurceramsoc.2007.06.009.
Release of DL- leucine by biomaterials: Apatitic calcium phosphates analogous to bone mineral / A. E. Rhilassi, M. Mourabet, H. E. Boujaady, H. Ramdane, M. Bennani-Ziatni, R. El Hamri, A. J. Taitai // Mater. Environ. Sci. – 2012. – Vol. 3, iss. 3. – P. 515–524.
Koroleva L. F. Nanocrystalline doped calcium carbonate-phosphates as a biomaterial for osteogenesis // Research Journal of Pharmaceutical, Biological and Chemical Sciences. – 2014. – Vol.5, iss. 6. – P. 704–710.Roveri
Roveri Norberto, Iafisco Michele. Evolving application of biomimetic nanostructured hydroxyapatite // Nanotechnology Science and Applications. – 2010. – Vol. 3. – P. 107–125. – DOI: 10.2147/NSA.S9038.

Библиографическая ссылка на статью

Koroleva L. F., Dobrinskaya M. N., Kamantsev I. S. Doped Nanocrystalline Calcium Carbonate-Phosphate – a Biomaterial for Bone Repair and Strengtheining by Drug Delivery // Diagnostics, Resource and Mechanics of materials and structures. - 2015. - Iss. 5. - P. 147-157. -
DOI: 10.17804/2410-9908.2015.5.147-157. -
URL: http://dream-journal.org/issues/content/article_40.html
(accessed: 21.12.2024).